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2 edition of In vitro measurement of nucleus pulposus swelling pressure found in the catalog.

In vitro measurement of nucleus pulposus swelling pressure

In vitro measurement of nucleus pulposus swelling pressure

a new technique for studies of spinal adaptation to gravity

  • 65 Want to read
  • 22 Currently reading

Published by National Aeronautics and Space Administration, Ames Research Center, National Technical Information Service, distributor in Moffett Field, Calif, [Springfield, Va.? .
Written in English

    Subjects:
  • Intervertebral disk.,
  • Reduced gravity environments.

  • Edition Notes

    StatementA.R. Hargens ... [et al.].
    SeriesNASA technical memorandum -- 103853.
    ContributionsHargens, Alan R., Ames Research Center.
    The Physical Object
    FormatMicroform
    Pagination1 v.
    ID Numbers
    Open LibraryOL17676332M

    nucleus [noo´kle-us] (pl. nu´clei) (L.) 1. cell nucleus; a spheroid body within a cell, contained in a double membrane, the nuclear envelope, and containing the chromosomes and one or more nucleoli. The contents are collectively referred to as nucleoplasm. The chromosomes contain deoxyribonucleic acid (DNA), which is the genetic material that codes.   Traumatic disc extrusions (TDE) may occur when an otherwise healthy intervertebral disc is subjected to excessive force such as during vigorous exercise (such as running and jumping) or trauma. A sudden increase in intradiscal pressure can cause rapid projection of hydrated nucleus pulposus (NP) toward the spinal cord through a tear in the.

    Full text of "Developmental adaptations to gravity in animals" on the side of the membrane opposite the sample of nucleus pulposus usually occurs when the swelling pressure of the nucleus pulposus is measured in a stan- dard osmometer. A new technique for the in vitro measurement of nucleus pulposus swelling pressure. /. Orthopaedic Res.   Elderly have shrunken, yellowed and dehydrated nucleus pulposus Common surgical specimen, obtained after intervertebral disc prolapse or herniation, which is most common in ages 20 - 39 years Anterior herniation usually is asymptomatic; posterior herniation puts pressure on nerve roots or spinal canal and produces symptoms.

    The Role of the Nucleus Pulposus in Human Intervertebral Disc Mechanical Function Quantified by Mechanical Loading and Non-Invasive Imaging Abstract The intervertebral disc performs the mechanical roles of supporting loads, permitting motion, and dissipating energy. A Well-Controlled Nucleus Pulposus Tissue Culture System with Injection Port for Evaluating Regenerative Therapies IRENE T. M. ARKESTEIJN, 1 VIVIAN H. M. MOUSER,1,2 FACKSON MWALE,3 BART G. M. VAN DIJK,1 and KEITA ITO 1,2 1Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box , MB Eindhoven, The Cited by: 3.


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In vitro measurement of nucleus pulposus swelling pressure Download PDF EPUB FB2

We have designed and tested a new osmometer for in vitro determination of nucleus pulposus swelling pressure. The functional principle of the osmometer involves compressing a sample of nucleus pulposus with nitrogen gas until saline pressure gradients across a μm Millipore filter are by: Get this from a library.

In vitro measurement of nucleus pulposus swelling pressure: a new technique for studies of spinal adaptation to gravity. [Alan R Hargens; Ames Research Center.;]. As ex vivo nucleus pulposus tissue explant cultures cannot be used to study cell metabolism because of the tissue swelling that occurs when placed in vitro [4, 11], we developed the methodology to form nucleus pulposus tissue in vitro.

The tissue resembles the native nucleus pulposus and allows for the study of nucleus pulposus cells in a 3 Cited by: 9. In the nucleus pulposus and inner annulus of bovine disks, application of hydrostatic pressure in the range of MPa In vitro measurement of nucleus pulposus swelling pressure book only 20 s stimulated matrix synthesis over the following 2 h at.

The nucleus pulposus, usually referred to as fluid, 13–17 loses its hydrostatic pressure feature. 1,18–23 A more fibrotic (increased collagen in nucleus pulposus) 10,24 tissue will not behave in the same manner as a fluid/gel nucleus pulposus.

The nucleus pulposus tissue undergoes a process of stiffening by means of gradual loss of Cited by: Request PDF | OnZhen Li and others published Polyurethane scaffold with in situ swelling capacity for nucleus pulposus replacement | Find, read and cite all the research you need on.

The nucleus pulposus of the disc functions to distribute hydraulic pressure in all directions within each intervertebral disc under compressive loads. The nucleus pulposus consists of large vacuolated notochord cells, small chondrocyte-like cells, collagen fibrils, and aggrecan, a proteoglycan that aggregates by binding to on: Fibrocartilaginous joint between spinal vertebrae.

Nucleus pulposus is the jelly-like substance in the middle of the intervertebral disc. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of collagen fibrils, proteoglycan aggrecans and nucleus pulposus cells.

Nucleus. nucleus pulposus: [ noo´kle-us ] (pl. nu´clei) (L.) 1. cell nucleus; a spheroid body within a cell, contained in a double membrane, the nuclear envelope, and containing the chromosomes and one or more nucleoli.

The contents are collectively referred to as nucleoplasm. The chromosomes contain deoxyribonucleic acid (DNA), which is the genetic. The nucleus pulposus is a mucoid protein that binds approximately three times its weight in water and allows for distribution of forces.

Gregory D. Cramer, in Clinical Anatomy of the Spine, Spinal Cord, and Ans (Third Edition), The nucleus pulposus (NP) is a rounded region located within the center of the IVD (see Fig. Effect of constraint on accumulation of newly synthesized proteoglycans and collagen by nucleus pulposus (NP) cells in the in vitro–formed NP tissue.

(Left) Nucleus pulposus cells were grown in culture for 2 weeks and then grown for an additional 5 days under different constraint conditions (none, intermediate, or high).Cited by: 5. The Journal of Orthopaedic Research, a publication of the Orthopaedic Research Society (ORS), is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.

The intervertebral disc is the largest avascular structure in the body. It arises from notochordal cells between the cartilaginous endplates, which regress from about 50% of the disc space at birth to about 5% in the adult, with chondrocytes replacing the notochordal cells.

Start studying Anatomy nucleus pulposus. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Nucleus pulposus is the inner core of the vertebral disc. The core is composed of a jelly-like material that consists of mainly water, as well as a loose network of collagen fibers.

The elastic inner structure allows the vertebral disc to withstand forces of compression and torsion. With age, the body's discs dehydrate and become stiffer. In vitro measurement of nucleus pulposus swelling pressure [microform]: a new technique for studies of The lumbar disc: a conservative management of the lumbar intervertebral disc / [by] Leon L.

Marshall. Spinal disc herniation is an injury to the cushioning and connective tissue between vertebrae, usually caused by excessive strain or trauma to the may result in back pain, pain or sensation in different parts of the body, and physical most conclusive diagnostic tool for disc herniation is MRI, and treatment may range from painkillers to lty: Orthopedics, neurosurgery.

Nucleus pulposus is the jelly-like substance in the middle of the intervertebral disc. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of collagen fibrils, proteoglPrice: $ The higher incidence of acute non-compressive nucleus pulposus extrusion at the junction between mobile lumbar segment of the vertebral column and the comparatively immobile thoracic segment of the vertebral column is likely attributable to the strong biomechanical forces that act at this junction, particularly during strenuous exercise or trauma.

Start studying Chapter 9 - Axial Skeleton. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Confined Compression of Canine Annulus Fibrosus Under Chemical and Mechanical Loading M. R. Drost. A New Technique for the In Vitro Measurement of Nucleus Pulposus Swelling Pressure,” J., Maroudas, A.,“Measurement of Swelling Pressure and Fluid Flow in the Intervertebral Disc With Respect to Creep.

Proc. Inst. by: An in vitro study of dynamic cyclic compressive stress on human inner annulus fibrosus and nucleus pulposus cells. Spine J. ; 5. Fernando HN, Czamanski J, Yuan TY, Gu W, Salahadin A, Huang CY.

Mechanical loading affects the energy metabolism of intervertebral disc cells. Aggrecan is one of the major macromolecular components of the intervertebral disc (IVD) and its loss is an early sign of degeneration. Restoration of aggrecan, and hence of biomechanical properties, is a major objective of biological therapies.

At present, assessment of aggrecan concentration via its glycosaminoglycan (GAG) content is accomplished using biochemical and histological methods Cited by: 7.